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Exploring the Size Limit of Templates for Inhibitors of the M2 Ion Channel of Influenza A Virus
Amantadine inhibits the M2 proton channel of influenza A virus, yet its clinical use has been limited by the rapid emergence of amantadine-resistant virus strains. We have synthesized and characterized a series of polycyclic compounds designed as ring-contracted or ring-expanded analogs of amantadin...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3174104/ https://ncbi.nlm.nih.gov/pubmed/21466220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101334y |
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