Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice

It is well known that insulin can activate both PI3K/Akt pathway, which is responsible for glucose uptake, and MAPK pathway, which is crucial for insulin resistance formation. But, it is unclear exactly how the two pathways coordinate to regulate insulin sensitivity upon hyperinsulinism stress of ty...

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Detalhes bibliográficos
Main Authors: Yu, Xiao, Shen, Ning, Zhang, Ming-Liang, Pan, Fei-Yan, Wang, Chen, Jia, Wei-Ping, Liu, Chang, Gao, Qian, Gao, Xiang, Xue, Bin, Li, Chao-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173797/
https://ncbi.nlm.nih.gov/pubmed/21829168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.277
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