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Vinblastine sensitizes leukemia cells to cyclin-dependent kinase inhibitors, inducing acute cell cycle phase-independent apoptosis

The efficacy of many chemotherapeutic agents can be attenuated by expression of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Mcl-1. Flavopiridol and dinaciclib are cyclin-dependent kinase 7 and 9 inhibitors that transcriptionally inhibit expression of Mcl-1. We have investigated the ability of fl...

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Detalhes bibliográficos
Main Authors: Bates, Darcy JP, Salerni, Bethany L, Lowrey, Christopher H, Eastman, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173732/
https://ncbi.nlm.nih.gov/pubmed/21768777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.12.4.16909
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