Discovery of Dual-Action Membrane-Anchored Modulators of Incretin Receptors

BACKGROUND: The glucose-dependent insulinotropic polypeptide (GIP) and the glucagon-like peptide-1 (GLP-1) receptors are considered complementary therapeutic targets for type 2 diabetes. Using recombinant membrane-tethered ligand (MTL) technology, the present study focused on defining optimized modu...

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Bibliographic Details
Main Authors: Fortin, Jean-Philippe, Chinnapen, Daniel, Beinborn, Martin, Lencer, Wayne, Kopin, Alan S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173463/
https://ncbi.nlm.nih.gov/pubmed/21935440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024693
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