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The proteasome inhibitor MG132 reduces immobilization-induced skeletal muscle atrophy in mice
BACKGROUND: Skeletal muscle atrophy is a serious concern for the rehabilitation of patients afflicted by prolonged limb restriction. This debilitating condition is associated with a marked activation of NFκB activity. The ubiquitin-proteasome pathway degrades the NFκB inhibitor IκBα, enabling NFκB t...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
BioMed Central
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3173404/ https://ncbi.nlm.nih.gov/pubmed/21843349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2474-12-185 |
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