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T cell receptor signal strength in T(reg) and iNKT cell development demonstrated by a novel fluorescent reporter mouse
The ability of antigen receptors to engage self-ligands with varying affinity is crucial for lymphocyte development. To further explore this concept, we generated transgenic mice expressing GFP from the immediate early gene Nr4a1 (Nur77) locus. GFP was up-regulated in lymphocytes by antigen receptor...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Rockefeller University Press
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3173240/ https://ncbi.nlm.nih.gov/pubmed/21606508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110308 |
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