Protein Phosphatase 2A and Neutral Sphingomyelinase 2 Regulate IRAK-1 Protein Ubiquitination and Degradation in Response to Interleukin-1β

The IL-1β signaling cascade is initiated by the phosphorylation of IL-1β receptor-associated kinase-1 (IRAK-1), followed by its ubiquitination and degradation. This paper investigates the regulation of IRAK-1 degradation in primary hepatocytes and in HEK cells overexpressing the IL-1β receptor. We p...

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Autori principali: Dobierzewska, Aneta, Giltiay, Natalia V., Sabapathi, Sathish, Karakashian, Alexander A., Nikolova-Karakashian, Mariana N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Lipids
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173202/
https://ncbi.nlm.nih.gov/pubmed/21708940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.238030
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