Transforming Growth Factor-β-activated Kinase 1 Regulates Natural Killer Cell-mediated Cytotoxicity and Cytokine Production

Carma1, a caspase recruitment domain-containing membrane-associated guanylate kinase, initiates a unique signaling cascade via Bcl10 and Malt1 in NK cells. Carma1 deficiency results in reduced phosphorylation of JNK1/2 and activation of NF-κB that lead to impaired NK cell-mediated cytotoxicity and c...

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Autori principali: Rajasekaran, Kamalakannan, Chu, Haiyan, Kumar, Pawan, Xiao, Yechen, Tinguely, Mathew, Samarakoon, Asanga, Kim, Tae Whan, Li, Xiaoxia, Thakar, Monica S., Zhang, Jiwang, Malarkannan, Subramaniam
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173069/
https://ncbi.nlm.nih.gov/pubmed/21771792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.261917
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