Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes

Rap1 GTPases control immune synapse formation and signaling in lymphocytes. However, the precise molecular mechanism by which Rap1 regulates natural killer (NK) cell activation is not known. Using Rap1a or Rap1b knockout mice, we identify Rap1b as the major isoform in NK cells. Its absence significa...

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Autors principals: Awasthi, Aradhana, Samarakoon, Asanga, Chu, Haiyan, Kamalakannan, Rajasekaran, Quilliam, Lawrence A., Chrzanowska-Wodnicka, Magdalena, White, Gilbert C., Malarkannan, Subramaniam
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2931159/
https://ncbi.nlm.nih.gov/pubmed/20733035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100040
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