Use of biotin targeted methotrexate–human serum albumin conjugated nanoparticles to enhance methotrexate antitumor efficacy

Biotin molecules could be used as suitable targeting moieties in targeted drug delivery systems against tumors. To develop a biotin targeted drug delivery system, we employed human serum albumin (HSA) as a carrier. Methotrexate (MTX) molecules were conjugated to HSA. MTX-HSA nanoparticles (MTX-HSA N...

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Main Authors: Taheri, Azade, Dinarvand, Rassoul, Nouri, Faranak Salman, Khorramizadeh, Mohammad Reza, Borougeni, Atefeh Taheri, Mansoori, Pooria, Atyabi, Fatemeh
Formato: Artigo
Idioma:Inglês
Publicado: Dove Medical Press 2011
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173049/
https://ncbi.nlm.nih.gov/pubmed/21931482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S23949
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