Discovery of 7-Hydroxy-6-methoxy-2-methyl-3-(3,4,5- trimethoxybenzoyl)benzo[b]furan (BNC105), a Tubulin Polymerization Inhibitor with Potent Antiproliferative and Tumor Vascular Disrupting Properties

[Image: see text] A structure–activity relationship (SAR) guided design of novel tubulin polymerization inhibitors has resulted in a series of benzo[b]furans with exceptional potency toward cancer cells and activated endothelial cells. The potency of early lead compounds has been substantially impro...

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Detalhes bibliográficos
Main Authors: Flynn, Bernard L., Gill, Gurmit S., Grobelny, Damian W., Chaplin, Jason H., Paul, Dharam, Leske, Annabell F., Lavranos, Tina C., Chalmers, David K., Charman, Susan A., Kostewicz, Edmund, Shackleford, David M., Morizzi, Julia, Hamel, Ernest, Jung, M. Katherine, Kremmidiotis, Gabriel
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172808/
https://ncbi.nlm.nih.gov/pubmed/21774499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200454y
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