Innate signals overcome acquired TCR signaling pathway regulation and govern the fate of human CD161(hi) CD8α(+) semi-invariant T cells

Type 17 programmed CD161(hi)CD8α(+) T cells contribute to mucosal immunity to bacteria and yeast. In early life, microbial colonization induces proliferation of CD161(hi) cells that is dependent on their expression of a semi-invariant Vα7.2(+) TCR. Although prevalent in adults, CD161(hi)CD8α(+) cell...

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Detalhes bibliográficos
Main Authors: Turtle, Cameron J., Delrow, Jeff, Joslyn, Rochelle C., Swanson, Hillary M., Basom, Ryan, Tabellini, Laura, Delaney, Colleen, Heimfeld, Shelly, Hansen, John A., Riddell, Stanley R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172793/
https://ncbi.nlm.nih.gov/pubmed/21791427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-334698
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