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Serine metabolism: some tumors take the road less traveled

Cancer cells display a reprogramming of metabolism that facilitates growth but addicts them to key enzyme activities. Two studies in Nature and Nature Genetics find that the gene encoding the serine biosynthetic enzyme phosphoglycerate dehydrogenase (PHGDH) is amplified in a subset of cancers and co...

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Detalles Bibliográficos
Autor principal: DeBerardinis, Ralph J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172581/
https://ncbi.nlm.nih.gov/pubmed/21907134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.08.004
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