The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein

HIV-1 Tat activates transcription through binding to human cyclin T1, a regulatory subunit of the TAK/P-TEFb CTD kinase complex. Here we show that the cyclin domain of hCycT1 is necessary and sufficient to interact with Tat and promote cooperative binding to TAR RNA in vitro, as well as mediate Tat...

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מידע ביבליוגרפי

הוצא לאור ב:	Genes Dev
Principais autores:	Garber, Mitchell E., Wei, Ping, KewalRamani, Vineet N., Mayall, Timothy P., Herrmann, Christine H., Rice, Andrew P., Littman, Dan R., Jones, Katherine A.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Cold Spring Harbor Laboratory Press 1998
נושאים:	Research Paper
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317238/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9832504/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.22.3512
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