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The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein

HIV-1 Tat activates transcription through binding to human cyclin T1, a regulatory subunit of the TAK/P-TEFb CTD kinase complex. Here we show that the cyclin domain of hCycT1 is necessary and sufficient to interact with Tat and promote cooperative binding to TAR RNA in vitro, as well as mediate Tat...

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Publicado no:Genes Dev
Principais autores: Garber, Mitchell E., Wei, Ping, KewalRamani, Vineet N., Mayall, Timothy P., Herrmann, Christine H., Rice, Andrew P., Littman, Dan R., Jones, Katherine A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 1998
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317238/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9832504/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.22.3512
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