Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regulated

Cellular stress can globally inhibit translation initiation, and glucose removal from yeast causes one of the most dramatic effects in terms of rapidity and scale. Here we show that the same rapid inhibition occurs during yeast growth as glucose levels diminish. We characterize this novel regulation...

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Main Authors: Castelli, Lydia M., Lui, Jennifer, Campbell, Susan G., Rowe, William, Zeef, Leo A. H., Holmes, Leah E. A., Hoyle, Nathaniel P., Bone, Jonathon, Selley, Julian N., Sims, Paul F. G., Ashe, Mark P.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2011
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172263/
https://ncbi.nlm.nih.gov/pubmed/21795399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-02-0153
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