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ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage

DNA polymerase η (polη) belongs to the Y-family of DNA polymerases and facilitates translesion synthesis past UV damage. We show that, after UV irradiation, polη becomes phosphorylated at Ser601 by the ataxia-telangiectasia mutated and Rad3-related (ATR) kinase. DNA damage–induced phosphorylation of...

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Detalhes bibliográficos
Main Authors: Göhler, Thomas, Sabbioneda, Simone, Green, Catherine M., Lehmann, Alan R.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172178/
https://ncbi.nlm.nih.gov/pubmed/21242293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201008076
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