Dosing regimens of oral ciprofloxacin for children with severe malnutrition: a population pharmacokinetic study with Monte Carlo simulation

BACKGROUND: Severe malnutrition is frequently complicated by sepsis, leading to high case fatality. Oral ciprofloxacin is a potential alternative to the standard parenteral ampicillin/gentamicin combination, but its pharmacokinetics in malnourished children is unknown. METHODS: Ciprofloxacin (10 mg/...

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Detalhes bibliográficos
Main Authors: Thuo, Nahashon, Ungphakorn, Wanchana, Karisa, Japhet, Muchohi, Simon, Muturi, Alex, Kokwaro, Gilbert, Thomson, Alison H., Maitland, Kathryn
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172043/
https://ncbi.nlm.nih.gov/pubmed/21831986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkr314
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