Caspase-9 and APAF-1 form an active holoenzyme
Autocatalytic activation of initiator caspases is the link between pro-apoptotic signals and the destruction machinery of apoptosis. Activation of caspase-9, which mediates oncogene and drug-induced apoptosis, requires binding to the protein APAF-1. We found that the proteolytic activity of caspase-...
Salvato in:
| Pubblicato in: | Genes Dev |
|---|---|
| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
1999
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317200/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10617566/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.24.3179 |
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