O-glycosylation of the cardiac I(Ks) complex

ABSTRACT: Post-translational modifications of the KCNQ1–KCNE1 (Kv7) K(+) channel complex are vital for regulation of the cardiac I(Ks) current and action potential duration. Here, we show the KCNE1 regulatory subunit is O-glycosylated with mucin-type glycans in vivo. As O-linked glycosylation sites...

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Autori principali: Chandrasekhar, Kshama D, Lvov, Anatoli, Terrenoire, Cecile, Gao, Grace Y, Kass, Robert S, Kobertz, William R
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2011
Soggetti:
Molecular and Cellular
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171881/
https://ncbi.nlm.nih.gov/pubmed/21669976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2011.211284
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