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Assessment of dopamine D(1) receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393
To assess the effect of conformational mobility on receptor activity, the β-phenyl substituent of dopamine D(1) agonist ligands of the phenylbenzazepine class, (±)-6,6a,7,8,9,13b-hexahydro-5Hbenzo[d]naphtho[2,1-b]azepine-11,12-diol (8), and its oxygen and sulfur bioisosteres 9 and 10, respectively,...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3171562/ https://ncbi.nlm.nih.gov/pubmed/21862338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.07.057 |
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