Nuclear matrix attachment regions antagonize methylation-dependent repression of long-range enhancer–promoter interactions

The immunoglobulin intragenic μ enhancer region acts as a locus control region that mediates transcriptional activation over large distances in germ line transformation assays. In transgenic mice, but not in transfected tissue culture cells, the activation of a variable region (V(H)) promoter by the...

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Bibliographic Details
Main Authors: Forrester, William C., Fernández, Luis A., Grosschedl, Rudolf
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 1999
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC317154/
https://ncbi.nlm.nih.gov/pubmed/10580007
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