Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1)
The p16(INK4a) tumor suppressor inhibits cyclin-dependent kinases (CDK4 and CDK6). Here we report the isolation of a novel gene, SEI-1, whose product (p34(SEI-1)) appears to antagonize the function of p16(INK4a). Addition of p34(SEI-1) to cyclin D1–CDK4 renders the complex resistant to inhibition by...
Zapisane w:
| Wydane w: | Genes Dev |
|---|---|
| Główni autorzy: | , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Cold Spring Harbor Laboratory Press
1999
|
| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317153/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10580009/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.22.3027 |
| Etykiety: |
Nie ma etykietki, Dołącz pierwszą etykiete!
|
