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Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1)

The p16(INK4a) tumor suppressor inhibits cyclin-dependent kinases (CDK4 and CDK6). Here we report the isolation of a novel gene, SEI-1, whose product (p34(SEI-1)) appears to antagonize the function of p16(INK4a). Addition of p34(SEI-1) to cyclin D1–CDK4 renders the complex resistant to inhibition by...

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Udgivet i:Genes Dev
Principais autores: Sugimoto, Masataka, Nakamura, Takeshi, Ohtani, Naoko, Hampson, Lynne, Hampson, Ian N., Shimamoto, Akira, Furuichi, Yasuhiro, Okumura, Ko, Niwa, Shinichiro, Taya, Yoichi, Hara, Eiji
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 1999
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317153/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10580009/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.22.3027
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