MET phosphorylation predicts poor outcome in small cell lung carcinoma and its inhibition blocks HGF-induced effects in MET mutant cell lines

BACKGROUND: Small cell lung carcinoma (SCLC) has poor prognosis and remains orphan from targeted therapy. MET is activated in several tumour types and may be a promising therapeutic target. METHODS: To evaluate the role of MET in SCLC, MET gene status and protein expression were evaluated in a panel...

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Detalhes bibliográficos
Main Authors: Arriola, E, Cañadas, I, Arumí-Uría, M, Dómine, M, Lopez-Vilariño, J A, Arpí, O, Salido, M, Menéndez, S, Grande, E, Hirsch, F R, Serrano, S, Bellosillo, B, Rojo, F, Rovira, A, Albanell, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171012/
https://ncbi.nlm.nih.gov/pubmed/21847116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.298
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