Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

The bmi-1 and myc oncogenes collaborate strongly in murine lymphomagenesis, but the basis for this collaboration was not understood. We recently identified the ink4a–ARF tumor suppressor locus as a critical downstream target of the Polycomb-group transcriptional repressor Bmi-1. Others have shown th...

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Pubblicato in:	Genes Dev
Autori principali:	Jacobs, Jacqueline J.L., Scheijen, Blanca, Voncken, Jan-Willem, Kieboom, Karin, Berns, Anton, van Lohuizen, Maarten
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 1999
Soggetti:	Research Paper
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317101/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10541554/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.20.2678
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