Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

The bmi-1 and myc oncogenes collaborate strongly in murine lymphomagenesis, but the basis for this collaboration was not understood. We recently identified the ink4a–ARF tumor suppressor locus as a critical downstream target of the Polycomb-group transcriptional repressor Bmi-1. Others have shown th...

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Detalhes bibliográficos
Main Authors: Jacobs, Jacqueline J.L., Scheijen, Blanca, Voncken, Jan-Willem, Kieboom, Karin, Berns, Anton, van Lohuizen, Maarten
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 1999
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC317101/
https://ncbi.nlm.nih.gov/pubmed/10541554
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