GSI-I (Z-LLNle-CHO) inhibits γ-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia

Gamma secretase inhibitors (GSIs) comprise a growing class of compounds that interfere with the membrane-bound Notch signaling protein and its downstream intra-nuclear transcriptional targets. As GSI-I (Z-LLNle-CHO) is also a derivative of a widely used proteosome inhibitor MG-132, we hypothesized t...

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Detalhes bibliográficos
Main Authors: Meng, X, Matlawska-Wasowska, K, Girodon, F, Mazel, T, Willman, C L, Atlas, S, Chen, I-M, Harvey, R C, Hunger, S P, Ness, S A, Winter, S S, Wilson, B S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170956/
https://ncbi.nlm.nih.gov/pubmed/21494254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.50
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