Cap methyltransferase selective binding and methylation of GpppG-RNA are stimulated by importin-α

We screened a human cDNA library for proteins that bind mRNA cap methyltransferase (MT) and isolated nuclear transporter importin-α (Impα). This direct association was confirmed by glutathione S-transferase (GST) pulldown, coimmunoprecipitation, and nuclear colocalization. In gel shift assays, MT se...

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Publié dans:	Genes Dev
Auteurs principaux:	Wen, Yingxia, Shatkin, Aaron J.
Format:	Artigo
Langue:	Inglês
Publié:	Cold Spring Harbor Laboratory Press 2000
Sujets:	Research Communication
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317093/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11114884/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.848200
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