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The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3′ end formation by two distinct mechanisms

The poly(A) signal of the C2 complement gene is unusual in that it possesses an upstream sequence element (USE) required for full activity in vivo. We describe here in vitro experiments demonstrating that this USE enhances both the cleavage and poly(A) addition reactions. We also show that the C2 US...

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Auteurs principaux: Moreira, Alexandra, Takagaki, Yoshio, Brackenridge, Simon, Wollerton, Matthew, Manley, James L., Proudfoot, Nicholas J.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 1998
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC317083/
https://ncbi.nlm.nih.gov/pubmed/9716405
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