Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors

BACKGROUND: Betulinic acid (BA) inhibits growth of several cancer cell lines and tumors and the effects of BA have been attributed to its mitochondriotoxicity and inhibition of multiple pro-oncogenic factors. Previous studies show that BA induces proteasome-dependent degradation of specificity prote...

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Autores principales: Chintharlapalli, Sudhakar, Papineni, Sabitha, Lei, Ping, Pathi, Satya, Safe, Stephen
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170653/
https://ncbi.nlm.nih.gov/pubmed/21864401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-371
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