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Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?
SUMMARY: Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene strongly predispose to development of gastro-intestinal tumors. Central to the tumorigenic events in APC mutant cells is the uncontrolled stabilization and transcriptional activation of the protein β-catenin. Many quest...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3170638/ https://ncbi.nlm.nih.gov/pubmed/21859464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-101 |
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