Cannabinoid receptor-mediated translocation of NO-sensitive guanylyl cyclase and production of cyclic GMP in neuronal cells

Cannabinoid agonists regulate NO and cyclic AMP production in N18TG2 neuroblastoma cells, leading to the hypothesis that neuronal cyclic GMP production could be regulated by CB(1) cannabinoid receptors. NO (nitric oxide)-sensitive guanylyl cyclase (GC) is a heterodimeric cytosolic protein that media...

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Hauptverfasser: Jones, Jenelle D., Carney, Skyla T., Vrana, Kent E., Norford, Derek C., Howlett, Allyn C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170565/
https://ncbi.nlm.nih.gov/pubmed/17707868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2007.06.027
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