Context-dependent EKLF responsiveness defines the developmental specificity of the human ɛ-globin gene in erythroid cells of YAC transgenic mice

We explored the mechanism of definitive-stage ɛ-globin transcriptional inactivity within a human β-globin YAC expressed in transgenic mice. We focused on the globin CAC and CAAT promoter motifs, as previous laboratory and clinical studies indicated a pivotal role for these elements in globin gene ac...

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Argitaratua izan da:	Genes Dev
Egile Nagusiak:	Tanimoto, Keiji, Liu, Qinghui, Grosveld, Frank, Bungert, Jörg, Engel, James Douglas
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Cold Spring Harbor Laboratory Press 2000
Gaiak:	Research Paper
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317038/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11069894/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.822500
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