Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

Despite a strong correlation between telomerase activity and malignancy, the outcome of telomerase inhibition in human tumor cells has not been examined. Here, we have addressed the role of telomerase activity in the proliferation of human tumor and immortal cells by inhibiting TERT function. Induci...

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Vydáno v:	Genes Dev
Hlavní autoři:	Zhang, Xiaoling, Mar, Vernon, Zhou, Wen, Harrington, Lea, Robinson, Murray O.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Cold Spring Harbor Laboratory Press 1999
Témata:	Research Paper
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317024/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10500096/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.18.2388
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