Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

Despite a strong correlation between telomerase activity and malignancy, the outcome of telomerase inhibition in human tumor cells has not been examined. Here, we have addressed the role of telomerase activity in the proliferation of human tumor and immortal cells by inhibiting TERT function. Induci...

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Pubblicato in:	Genes Dev
Autori principali:	Zhang, Xiaoling, Mar, Vernon, Zhou, Wen, Harrington, Lea, Robinson, Murray O.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 1999
Soggetti:	Research Paper
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317024/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10500096/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.18.2388
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