Between-centre differences and treatment effects in randomized controlled trials: A case study in traumatic brain injury

BACKGROUND: In Traumatic Brain Injury (TBI), large between-centre differences in outcome exist and many clinicians believe that such differences influence estimation of the treatment effect in randomized controlled trial (RCTs). The aim of this study was to assess the influence of between-centre dif...

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Bibliografski detalji
Glavni autori: Lingsma, Hester F, Roozenbeek, Bob, Perel, Pablo, Roberts, Ian, Maas, Andrew IR, Steyerberg, Ewout W
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170218/
https://ncbi.nlm.nih.gov/pubmed/21867540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6215-12-201
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