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Between-centre differences and treatment effects in randomized controlled trials: A case study in traumatic brain injury

BACKGROUND: In Traumatic Brain Injury (TBI), large between-centre differences in outcome exist and many clinicians believe that such differences influence estimation of the treatment effect in randomized controlled trial (RCTs). The aim of this study was to assess the influence of between-centre dif...

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Detalhes bibliográficos
Main Authors: Lingsma, Hester F, Roozenbeek, Bob, Perel, Pablo, Roberts, Ian, Maas, Andrew IR, Steyerberg, Ewout W
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170218/
https://ncbi.nlm.nih.gov/pubmed/21867540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6215-12-201
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