Multicomponent synthesis of artificial nucleases and their RNase and DNase activity

The synthesis of new, artificial ribonucleases containing two amino acid residues connected by an aliphatic linker has been developed. Target molecules were synthesized via a catalytic three-component Ugi reaction from aliphatic diisocyanides. Preliminary investigations proved unspecific nuclease ac...

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Autori principali: Gulevich, Anton V, Koroleva, Lyudmila S, Morozova, Olga V, Bakhvalova, Valentina N, Silnikov, Vladimir N, Nenajdenko, Valentine G
Natura: Artigo
Lingua:Inglês
Pubblicazione: Beilstein-Institut 2011
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Full Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170195/
https://ncbi.nlm.nih.gov/pubmed/21915218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.7.131
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