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Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease
Niemann-Pick type C1 (NPC1) disease is a rare progressive neurodegenerative disorder characterized by endolysosomal cholesterol accumulation. Previous studies implicating oxidative stress in NPC1 disease pathogenesis raised the possibility that non-enzymatic formation of cholesterol oxidation produc...
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| 主要な著者: | , , , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3170139/ https://ncbi.nlm.nih.gov/pubmed/21048217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3001417 |
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