Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking

Niemann-Pick C1 (NPC1) is a key participant in cellular cholesterol trafficking. Loss of NPC1 function leads to defective suppression of SREBP-dependent gene expression and failure to appropriately activate liver X receptor–mediated (LXR-mediated) pathways, ultimately resulting in intracellular chol...

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Hlavní autoři: Zhang, Jessie R., Coleman, Trey, Langmade, S. Joshua, Scherrer, David E., Lane, Lindsay, Lanier, M. Hunter, Feng, Chu, Sands, Mark S., Schaffer, Jean E., Semenkovich, Clay F., Ory, Daniel S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2008
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2381744/
https://ncbi.nlm.nih.gov/pubmed/18483620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32561
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