Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease

Niemann-Pick type C1 (NPC1) disease is a rare progressive neurodegenerative disorder characterized by endolysosomal cholesterol accumulation. Previous studies implicating oxidative stress in NPC1 disease pathogenesis raised the possibility that non-enzymatic formation of cholesterol oxidation produc...

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Autores principales: Porter, Forbes D., Scherrer, David E., Lanier, Michael H., Langmade, S. Joshua, Molugu, Vasumathi, Gale, Sarah E., Olzeski, Dana, Sidhu, Rohini, Dietzen, Dennis J., Fu, Rao, Wassif, Christopher A., Yanjanin, Nicole M., Marso, Steven P., House, John, Vite, Charles, Schaffer, Jean E., Ory, Daniel S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170139/
https://ncbi.nlm.nih.gov/pubmed/21048217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3001417
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