Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease

Niemann-Pick type C1 (NPC1) disease is a rare progressive neurodegenerative disorder characterized by endolysosomal cholesterol accumulation. Previous studies implicating oxidative stress in NPC1 disease pathogenesis raised the possibility that non-enzymatic formation of cholesterol oxidation produc...

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Auteurs principaux: Porter, Forbes D., Scherrer, David E., Lanier, Michael H., Langmade, S. Joshua, Molugu, Vasumathi, Gale, Sarah E., Olzeski, Dana, Sidhu, Rohini, Dietzen, Dennis J., Fu, Rao, Wassif, Christopher A., Yanjanin, Nicole M., Marso, Steven P., House, John, Vite, Charles, Schaffer, Jean E., Ory, Daniel S.
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170139/
https://ncbi.nlm.nih.gov/pubmed/21048217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3001417
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