The aging systemic milieu negatively regulates neurogenesis and cognitive function

In the central nervous system (CNS), aging results in a precipitous decline in adult neural stem/progenitor cells (NPCs) and neurogenesis, with concomitant impairments in cognitive functions(1). Interestingly, such impairments can be ameliorated through systemic perturbations such as exercise(1). He...

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Hlavní autoři: Villeda, Saul A., Luo, Jian, Mosher, Kira I., Zou, Bende, Britschgi, Markus, Bieri, Gregor, Stan, Trisha M., Fainberg, Nina, Ding, Zhaoqing, Eggel, Alexander, Lucin, Kurt M., Czirr, Eva, Park, Jeong-Soo, Couillard-Després, Sebastien, Aigner, Ludwig, Li, Ge, Peskind, Elaine R., Kaye, Jeffrey A., Quinn, Joseph F., Galasko, Douglas R., Xie, Xinmin S., Rando, Thomas A., Wyss-Coray, Tony
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170097/
https://ncbi.nlm.nih.gov/pubmed/21886162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10357
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