A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo

Translation initiation factor 2 (eIF2) bound to GTP transfers the initiator methionyl tRNA to the 40S ribosomal subunit. The eIF5 stimulates GTP hydrolysis by the eIF2/GTP/Met-tRNA(i)(Met) ternary complex on base-pairing between Met-tRNA(i)(Met) and the start codon. The eIF2, eIF5, and eIF1 all have...

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Bibliographic Details

Published in:	Genes Dev
Main Authors:	Asano, Katsura, Clayton, Jason, Shalev, Anath, Hinnebusch, Alan G.
Format:	Artigo
Language:	Inglês
Published:	Cold Spring Harbor Laboratory Press 2000
Subjects:	Research Paper
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316978/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11018020/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.831800
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