Functional polymorphisms in UDP-glucuronosyltransferases and recurrence in tamoxifen-treated breast cancer survivors

BACKGROUND: Tamoxifen is oxidized by cytochrome-P450 enzymes (e.g., CYP2D6) to two active metabolites, which are eliminated via glucuronidation by UDP-glucuronosyltransferases (UGTs). We measured the association between functional polymorphisms in key UGTs (UGT2B15*2, UGT2B7*2, and UGT1A8*3) and the...

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Detalhes bibliográficos
Main Authors: Ahern, Thomas P., Christensen, Mariann, Cronin-Fenton, Deirdre P., Lunetta, Kathryn L., Søiland, Håvard, Gjerde, Jennifer, Garne, Jens Peter, Rosenberg, Carol L., Silliman, Rebecca A., Sørensen, Henrik Toft, Lash, Timothy L., Hamilton-Dutoit, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169710/
https://ncbi.nlm.nih.gov/pubmed/21750172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-11-0419
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