GRIM-1, a Novel Growth Suppressor, Inhibits rRNA Maturation by Suppressing Small Nucleolar RNAs

We have recently isolated novel IFN-inducible gene, Gene associated with Retinoid-Interferon-induced Mortality-1 (GRIM-1), using a genetic technique. Moderate ectopic expression of GRIM-1 caused growth inhibition and sensitized cells to retinoic acid (RA)/IFN-induced cell death while high expression...

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Autori principali: Nallar, Shreeram C., Lin, Limei, Srivastava, Varsha, Gade, Padmaja, Hofmann, Edward R., Ahmed, Hafiz, Reddy, Sekhar P., Kalvakolanu, Dhananjaya V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169572/
https://ncbi.nlm.nih.gov/pubmed/21931644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024082
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