Restoration of IFNγR Subunit Assembly, IFNγ Signaling and Parasite Clearance in Leishmania donovani Infected Macrophages: Role of Membrane Cholesterol

Despite the presence of significant levels of systemic Interferon gamma (IFNγ), the host protective cytokine, Kala-azar patients display high parasite load with downregulated IFNγ signaling in Leishmania donovani (LD) infected macrophages (LD-MØs); the cause of such aberrant phenomenon is unknown. H...

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Main Authors: Sen, Subha, Roy, Koushik, Mukherjee, Sandip, Mukhopadhyay, Rupkatha, Roy, Syamal
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169561/
https://ncbi.nlm.nih.gov/pubmed/21931549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002229
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