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High-level inhibition of mitochondrial complexes III and IV is required to increase glutamate release from the nerve terminal
BACKGROUND: The activities of mitochondrial complex III (ubiquinol-cytochrome c reductase, EC 1.10.2.2) and complex IV (cytochrome c oxidase EC 1.9.3.1) are reduced by 30-70% in Huntington's disease and Alzheimer's disease, respectively, and are associated with excitotoxic cell death in th...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3169489/ https://ncbi.nlm.nih.gov/pubmed/21791084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-53 |
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