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A nonproteolytic function of the proteasome is required for the dissociation of Cdc2 and cyclin B at the end of M phase

Inactivation of cyclin B–Cdc2 kinase at the exit from M phase depends on the specific proteolysis of the cyclin B subunit, whereas the Cdc2 subunit remains present at nearly constant levels throughout the cell cycle. It is unknown how Cdc2 escapes degradation when cyclin B is destroyed. In Xenopus e...

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Udgivet i:Genes Dev
Principais autores: Nishiyama, Atsuya, Tachibana, Kazunori, Igarashi, Yuko, Yasuda, Hideyo, Tanahashi, Nobuyuki, Tanaka, Keiji, Ohsumi, Keita, Kishimoto, Takeo
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2000
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316931/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10995390/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.823200
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